Monday, 26 September, 2022

International Healthcare Strategies For Rapid Drug Discovery Of Corona Virus


As we all know there is a race to find out appropriate treatment of coronavirus. Many researchers are working for specific drug to fight against this zoonotic disease namely coronavirus.

India is also playing a vital role for it.

Scientist from some innovative labs of Hyderabad with the help of artificial intelligence is working to create a new molecule which may show some capabilities to fight against the novel coronavirus (SARS-COV-12) based on its structure. The main target on virus maybe its spike protein which helps it to attach with host. We are working mainly on two new designed molecules which have similarity with the drug aurantiamide (antiviral compound).
Researches are working to design a new molecule which main show some properties of protease inhibitor as virus causes spike protein on its outer surface through which it infuses protein in the host for replication purpose.


Gimsilumab
Gimsilumab (human monoclonal antibody) is also under discovery by roviant sciences which main target GM-CSF and reduces lung damage in covid-19 patients.


TSM2
TSM2 (neutralizing antibody) is also under investigation by I-Mab Biopharma which works on the same factor GM-CSF.


TZLS-501
Tiziana life sciences is also giving their contribution by developing monoclonal antibody (TZLS-501) which may work on anti interleukin-6 receptor (IL-6R), which may reduce the chronic lung infection.


OYA1
OYA1 by Oyagen may also show antiviral efficacy, maybe in future it will show better results than chlorpromazine HCL.

Airway therapeutics is also trying to explore a novel recombinant protein AT-100 against this pandemic disease covid-19 which may result in reduction of inflammation and infection of lungs.


BPI-002
BPI-002 may also result in a innovative molecule by beyond spring which may activate CD4+ helper T cells and CD8+ cytotoxic T cells.


Idenprodil (NP-120)
Idenprodil(NP-120) main fruits as potential and effective drug against covid-19. This molecule is NMDA receptor antagonist.


APN01
APN01 which is ACE2 receptor may act on the receptor of virus which is most effective for the infusion of protein in the host.
This molecule is under search by University of British Columbia and APEIRON biologics.


Brilacidin

Brilacidin may show special defensive action against coronavirus by innovation pharmaceuticals.


Leronlimab (PRO140)

Leronlimab (PRO140) main show CCRS antagonist activity and maybe a good initiative against coronavirus. This drug is under investigation by CytoDyn.


BX-25
BIOXYTRAN has also announced that BX-25 drug molecule main lead in this pandemic situation of covid-19. This molecule may help patients which are surviving from acute respiratory distress syndrome (ARDS).


INO-4700
Inovia Pharma is also investigating a new molecule based on DNA immunotherapy namely INO-4700.


Remdesivir (GS-5734)
In the same way Gilead Science is also trying to find out a new drug molecule which supposed to be have effective potential against this coronavirus disease. They name the drug Remdesivir (GS-5734) which was known for the Ebola drug but unfortunately it was failed during that time. Now it is under investigation to fight against coronavirus.


Actemra
Actemra may also show some capability to increase immune response in coronavirus patients which is under investigation by Roche.
Galidesivir (BCX4430)
Galidesivir (BCX4430) an antiviral drug may show life protecting benefits against coronavirus which is a drug molecule of Biocryst Pharma.


REGN3048-3051
Regeneron has also a new drug molecule namely REGN3048-3051 which may show promising effects to kill coronavirus.


SNG001
SNG001 is under research by Synairgen research which may act on lungs directly and may reduce the mortality rate of covid-19.


Aminoboost
Lattice biologics is also trying to find out an appropriate molecule against this pandemic disease coronavirus namely Aminoboost.

CEL-SCI is also trying to give their contribution to the world to fight effectively against coronavirus with the help of LEAPS peptide technology they are trying to develop an immunotherapy which may show antiviral and anti-inflammatory characters.

Plasma therapy may also show revolutionary changes against this pandemic disease of coronavirus which is under research by Takeda pharmaceuticals.

Other drugs like HIV drug molecule (Lopinavir/Ritonavir) antimalarial, antiviral, etc. under investigation for the treatment of this virus.

Ayurvedic system of medicine may also show some beneficial effect against coronavirus.

Conclusion
Hence researches are giving their contribution to design a new molecule either it may be any antibody, antiviral compound, vaccine, immunotherapy, plasma therapy, or any traditional therapy.

Apart from drug discovery other healthcare strategies are also under trial such as to increase immune response of an individual by performing yoga therapy, by taking different Indian traditional formulations, hot water, and etc. which may show some promising effects against this Chinese virus.

Every country is trying to help the world and want to give shield to their as well as people of other country and fight unitedly against coronavirus.

Thus, based on some hypothesis and researches scientists are trying to find out new drug molecule and effective treatment strategy against covid-19.

Name of Blogger: Priya Damwani
ARPB Blogger ID: ARPBGZ278

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