As we all know there is a race to find out appropriate treatment of coronavirus. Many researchers are working for specific drug to fight against this zoonotic disease namely coronavirus.
India
is also playing a vital role for it.
Scientist
from some innovative labs of Hyderabad with the help of artificial intelligence
is working to create a new molecule which may show some capabilities to fight
against the novel coronavirus (SARS-COV-12) based on its structure. The main
target on virus maybe its spike protein which helps it to attach with host. We
are working mainly on two new designed molecules which have similarity with the
drug aurantiamide (antiviral compound).
Researches are working to design a new molecule
which main show some properties of protease inhibitor as virus causes spike
protein on its outer surface through which it infuses protein in the host for
replication purpose.
Gimsilumab
Gimsilumab (human monoclonal antibody) is also
under discovery by roviant sciences which main target GM-CSF and reduces lung
damage in covid-19 patients.
TSM2
TSM2 (neutralizing antibody) is also under
investigation by I-Mab Biopharma which works on the same factor GM-CSF.
TZLS-501
Tiziana life sciences is also giving their contribution
by developing monoclonal antibody (TZLS-501) which may work on anti
interleukin-6 receptor (IL-6R), which may reduce the chronic lung infection.
OYA1
OYA1 by Oyagen may also show antiviral efficacy,
maybe in future it will show better results than chlorpromazine HCL.
Airway therapeutics is also trying to explore a
novel recombinant protein AT-100 against this pandemic disease covid-19 which
may result in reduction of inflammation and infection of lungs.
BPI-002
BPI-002 may also result in a innovative molecule
by beyond spring which may activate CD4+ helper T cells and CD8+ cytotoxic T
cells.
Idenprodil
(NP-120)
Idenprodil(NP-120) main fruits as potential
and effective drug against covid-19. This molecule is NMDA receptor antagonist.
APN01
APN01 which is ACE2 receptor may act on the
receptor of virus which is most effective for the infusion of protein in the
host.
This molecule is under search by University
of British Columbia and APEIRON biologics.
Brilacidin
Brilacidin may show special defensive action against coronavirus by innovation pharmaceuticals.
Leronlimab (PRO140)
Leronlimab (PRO140) main show CCRS antagonist
activity and maybe a good initiative against coronavirus. This drug is under investigation
by CytoDyn.
BX-25
BIOXYTRAN has also announced that BX-25 drug
molecule main lead in this pandemic situation of covid-19. This molecule may
help patients which are surviving from acute respiratory distress syndrome
(ARDS).
INO-4700
Inovia Pharma is also investigating a new
molecule based on DNA immunotherapy namely INO-4700.
Remdesivir
(GS-5734)
In the same way Gilead Science is also
trying to find out a new drug molecule which supposed to be have effective
potential against this coronavirus disease. They name the drug Remdesivir
(GS-5734) which was known for the Ebola drug but unfortunately it was failed
during that time. Now it is under investigation to fight against coronavirus.
Actemra
Actemra may also show some capability to
increase immune response in coronavirus patients which is under investigation
by Roche.
Galidesivir
(BCX4430)
Galidesivir (BCX4430) an antiviral drug may
show life protecting benefits against coronavirus which is a drug molecule of
Biocryst Pharma.
REGN3048-3051
Regeneron has also a new drug molecule namely
REGN3048-3051 which may show promising effects to kill coronavirus.
SNG001
SNG001 is under research by Synairgen
research which may act on lungs directly and may reduce the mortality rate of
covid-19.
Aminoboost
Lattice biologics is also trying to find out
an appropriate molecule against this pandemic disease coronavirus namely Aminoboost.
CEL-SCI is also trying to give their
contribution to the world to fight effectively against coronavirus with the
help of LEAPS peptide technology they are trying to develop an immunotherapy
which may show antiviral and anti-inflammatory characters.
Plasma therapy may also show revolutionary
changes against this pandemic disease of coronavirus which is under research by
Takeda pharmaceuticals.
Other drugs like HIV drug molecule
(Lopinavir/Ritonavir) antimalarial, antiviral, etc. under investigation for the
treatment of this virus.
Ayurvedic system of medicine may also show some beneficial
effect against coronavirus.
Conclusion
Hence researches are giving their contribution
to design a new molecule either it may be any antibody, antiviral compound,
vaccine, immunotherapy, plasma therapy, or any traditional therapy.
Apart from drug discovery other healthcare
strategies are also under trial such as to increase immune response of an
individual by performing yoga therapy, by taking different Indian traditional
formulations, hot water, and etc. which may show some promising effects against
this Chinese virus.
Every country is trying to help the world and
want to give shield to their as well as people of other country and fight
unitedly against coronavirus.
Thus, based on some hypothesis and researches scientists are trying to find out new drug molecule and effective treatment strategy against covid-19.
ARPB Blogger ID: ARPBGZ278
